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  2. How to Judge the Quality of Inhibitors

How to Judge the Quality of Inhibitors

How do you know that the molecule you ordered is the molecule you received?

Most of products have similar colors。 Some of them, especially those supplied in small quantities or as lyophilized solids, may be difficult to identify visually。 These products may appear as a clear, thin film on the bottom and walls of the vial。 It is difficult to identify them with based on appearance alone。 For chemicals, the determination of the structures is carried out mainly by spectroscopic, such as Infrared spectroscopy (IR), Mass Spectrometry (MS), UV-VIS spectroscopy (UV), Nuclear Magnetic Resonance spectroscopy (NMR)。 NMR and MS are among the most commonly used methods for examining material properties。 MedChemExpress’ products have been analyzed using both NMR and MS。 Our customers can find the spectroscopic results used for product identification in the product’s Certificate of Analysis (COA) provided online。 The NMR and MS results are provided with each shipment to our Customers。 Specific analytical methods may also be requested from our Technical Service group。

What is Nuclear Magnetic Resonance (NMR)?

What is Mass Spectrometry (MS)?

Purity

The High-Performance Liquid Chromatography (HPLC) is a powerful method which chemists routinely use for purity checking. The purity of MedChemExpress’ products is available online in the COA. The HPLC can also be found for our customers in the shipment package.

What is High Performance Liquid Chromatography (HPLC)?

Chiral Purity

The separation of chiral products is a very important consideration for inhibitors because the majority of bioorganic molecules are chiral. Chirality is a major concern in the modern pharmaceutical industry. This interest can be attributed largely to a heightened awareness that enantiomers of a racemic drug may have different pharmacological activities, as well as different pharmacokinetic and pharmacodynamic effects. Measurements of enantiomeric excess (ee.) by chiral HPLC are quick and accurate, although the chiral stationary phase may only be useful for limited types of compounds. MedChemExpress provides chiral purity information online or in COA for each batch of chiral products. The spectrum is available with other analysis reports.

What is Chiral HPLC?

Enantiomeric excess of a mixture of enantiomers is numerically equal to its optical purity

The following relationships define the terms ee

The ee of HY-14622

ee=(99.6%-0.4%)/(99.6%+0.4%)=99.2%

 

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