1. Signaling Pathways
  2. PI3K/Akt/mTOR
  3. PTEN


PTEN (Phosphatase and tensin homologue deleted on chromosome 10), a phosphoinositide 3-phosphatase, is an important regulator of insulin-dependent signaling。 The loss or impairment of PTEN results in an antidiabetic impact, which led to the suggestion that PTEN could be an important target for drugs against type II diabetes。 PTEN has a much wider active site cleft enabling it to bind the PtdIns(3,4,5)P3 substrate。 a highly potent and specific inhibitor of PTEN that increases cellular PtdIns(3,4,5)P3 levels, phosphorylation of Akt, and glucose uptake in adipocytes at nanomolar concentrations。

PTEN 相关产品 (2):

Cat. No. Product Name Effect Purity
  • HY-13074
    VO-Ohpic trihydrate Inhibitor >98.0%
    VO-Ohpic trihydrate 是一种高效的 PTEN 抑制剂,IC50 为 46±10 nM。
  • HY-15842
    SF1670 Inhibitor >98.0%
    SF1670 是一种有效的特异性的人第10号染色体缺失的磷酸酶及张力蛋白同源蛋白 (PTEN) 抑制剂。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

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