1. Signaling Pathways
  2. Stem Cell/Wnt
  3. Notch

Notch

Notch signaling pathway is a highly conserved cell signaling system present in most multicellular organisms. Notch is present in all metazoans, and mammals possess four different notch receptors, referred to as Notch1, Notch2, Notch3, and Notch4. The notch receptor is a single-pass transmembrane receptor protein. It is a hetero-oligomer composed of a large extracellular portion, which associates in a calcium-dependent, non-covalent interaction with a smaller piece of the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region. Notch signaling promotes proliferative signaling during neurogenesis, and its activity is inhibited by Numb to promote neural differentiation. The notch signaling pathway is important for cell-cell communication, which involves gene regulation mechanisms that control multiple cell differentiation processes during embryonic and adult life.

Notch 相关产品 (16):

Cat. No. Product Name Effect Purity
  • HY-11102
    RO4929097 Inhibitor 98.02%
    RO4929097 (RG-4733) 是一种 γ secretase 抑制剂,IC50 值为 4 nM,能够抑制细胞内 Aβ40 的产生和 Notch 活性,EC50 值分别为 14 nM 和 5 nM。
  • HY-12449
    Crenigacestat Inhibitor 98.62%
    Crenigacestat (LY3039478) 是一个新的和强的Notch抑制剂。
  • HY-13526
    YO-01027 Inhibitor 99.23%
    YO-01027 (Dibenzazepine;DBZ)是高效的γ-分泌酶抑制剂,裂解NotchAPPLIC50分别为2.92±0.22和 2.64±0.30 nM。
  • HY-50752
    LY-411575 Inhibitor 98.71%
    LY-411575 是高效的 γ-secretase 抑制剂,能够抑制 Aβ40 蛋白的产生,其 IC50 值为 0.078 nM/0.082 nM(基于膜/细胞),同时抑制 Notch 分裂,IC50 值为 0.39 nM。
  • HY-N0133
    Tangeretin Inhibitor 99.10%
    Tangeretin (Tangeritin),黄酮类化合物,是Notch-1的有效抑制剂,具有抗炎,保护神经等作用。
  • HY-12860
    Notch inhibitor 1 Inhibitor
    Notch inhibitor 1 是一种有效的 Notch 的抑制剂,对 Notch 1 和 Notch 3 的 IC50 值分别为 7.8 和 8.5 nM。可用于癌症的研究。
  • HY-117113
    JI051 Inhibitor
    JI051 是一种 Hes1-PHB2 相互作用稳定剂,能够与癌症相关蛋白伴侣 prohibitin 2 (PHB2) 相互作用,通过抑制 Notch 下游效应基因 Hes1 来诱导细胞周期停滞。具有抗肿瘤作用。
  • HY-15860
    FLI-06 Inhibitor 99.87%
    FLI-06是Notch信号传导的抑制剂,EC50值为2.3 μM。
  • HY-100431
    IMR-1 Inhibitor 99.13%
    IMR-1是一个新的Notch抑制剂,针对转录激活,IC50是6 μmol/L.
  • HY-10009
    Semagacestat Inhibitor 98.83%
    Semagacestat 是一种 γ-secretase 抑制剂,抑制 β-amyloid (Aβ42),Aβ38Aβ40IC50 分别为 10.9,12 和 12.1 nM。也抑制 NotchIC50 为 14.1 nM。
  • HY-12465
    Z-Ile-Leu-aldehyde Inhibitor 98.10%
    Z-Ile-Leu-aldehyde(Z-IL-CHO; GSI-XII)是_gamma_-secretase抑制剂,Notch信号转导抑制剂。
  • HY-50845
    Avagacestat Inhibitor 99.93%
    Avagacestat (BMS-708163) 是有效的 γ-secretase 抑制剂,抑制 Aβ42 和 Aβ40 的产生,IC50 值分别为 0.27 nM 和 0.30 nM;BMS-708163 同时抑制 Notch 胞内结构域 (NICD) 和 CYP2C19,IC50 值分别为 0.84 nM 和 20 μM。
  • HY-12419
    BMS-983970 Inhibitor 99.21%
    BMS-983970是Notch口服性抑制剂,用于抗癌研究。
  • HY-100431A
    IMR-1A Inhibitor 98.06%
    IMR-1A是IMR-1的代谢物,IMR-1是一个新的靶点在转录活性上的Notch抑制剂,IC50是 6umol/L.
  • HY-N0232
    Psoralidin Inhibitor 98.13%
    补骨脂定(Psoralidin)是从补骨脂中分离出的一种天然呋喃香豆素,具有抗癌活性。
  • HY-104031
    tCFA15 Modulator
    tCFA15 为一种三甲基环己烯长链脂肪醇,侧链含有 15 个碳原子,能够促进神经细胞的分化,具有调控 Notch 信号通路的潜力。
Isoform Specific Products

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