1. Signaling Pathways
  2. GPCR/G Protein
  3. Glucocorticoid Receptor

Glucocorticoid Receptor

Glucocorticoid Receptor (GR, or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune response. When the glucocorticoid receptor binds to glucocorticoids, its primary mechanism of action is the regulation of gene transcription. The unbound receptor resides in the cytosol of the cell. After the receptor is bound to glucocorticoid, the receptor-glucorticoid complex can take either of two paths. The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus. Dexamethasone is an agonist, and RU486 and cyproterone acetate are antagonists of the GR. Also, progesterone and DHEA have antagonist effects on the GR.

Glucocorticoid Receptor 相关产品 (57):

Cat. No. Product Name Effect Purity
  • HY-14648
    Dexamethasone Agonist 99.85%
    Dexamethasone 是一种糖皮质激素受体 (glucocorticoid receptor) 激动剂。
  • HY-N0583
    Hydrocortisone Agonist 99.66%
    Hydrocortisone是肾上腺皮质分泌的类固醇激素或糖皮质激素。
  • HY-13683
    Mifepristone Antagonist 98.17%
    Mifepristone是黄体酮受体 (PR) 和糖皮质激素受体 (GR) 拮抗剂,体外实验中的 IC50 值分别为0.2 nM 和2.6 nM。
  • HY-B1618
    Corticosterone 99.07%
    Corticosterone是一种肾上腺皮质类固醇,作为盐皮质激素和糖皮质激素具有适度但显着的活性。
  • HY-17463
    Prednisolone Agonist >98.0%
    Prednisolone是糖皮质素。
  • HY-120012
    AZD9567 Modulator >99.0%
    AZD9567 (compound 15) 是一种有效的、具有口服活性的、非甾体类的、选择性糖皮质激素受体调节剂 (SGRM), 其 IC50 值为 3.8 nM。对 SCW 联合炎症表现出良好的疗效。
  • HY-113854
    AZD2906 Agonist 99.82%
    AZD2906 为一种选择性的糖皮质激素受体 glucocorticoid receptor (GR) 激动剂,能够增加大鼠骨髓中的微核未成熟红细胞。AZD290 对人、大鼠 PBMC 和全血中 GR 的 IC50 值分别为 2.2,0.3,41.6 和 7.5 nM。
  • HY-117880
    Exicorilant Antagonist
    Exicorilant (CORT 125281) 是选择性的、并具有口服活性的糖皮质激素受体 (GR) 的拮抗剂,其 Ki 值为 7 nM。Exicorilant (CORT 125281) 具有克服肥胖、葡萄糖不耐受和血脂异常的潜能。
  • HY-B1829A
    Dexamethasone phosphate disodium Agonist 99.68%
    Dexamethasone phosphate disodium is a glucocorticoid receptor agonist.
  • HY-B0260
    Methylprednisolone Agonist 99.67%
    Methylprednisolone是皮质类固醇,可作用于糖皮质激素受体。
  • HY-B0214
    Prednisone Agonist 99.35%
    Prednisone (Adasone)是皮质类固醇试剂,有免疫抑制作用。
  • HY-14648A
    Dexamethasone acetate Agonist 99.34%
    Dexamethasone是糖皮质素类甾体化合物,有抗炎和免疫抑制活性。
  • HY-13580
    Budesonide Agonist >98.0%
    Budesonide是一种具有强效抗炎活性的糖皮质类固醇
  • HY-N0835
    (20S)-Protopanaxatriol Agonist >98.0%
    (20S)-Protopanaxatriol 是人参皂苷的代谢物,通过 glucocorticoid receptoroestrogen receptor 起作用,同时为 LXRα 的抑制剂。
  • HY-B0328
    Triamcinolone Inhibitor 99.15%
    Triamcinolone是合成的长效糖皮质激素。
  • HY-B0154
    Fluticasone propionate Agonist 99.57%
    Fluticasone丙酸盐是糖皮质激素受体(GR)激动剂。
  • HY-14864
    Mapracorat Agonist 99.40%
    Mapracorat 是新型的非甾类有选择性的 glucocorticoid receptor 激动剂。
  • HY-15709
    AL 082D06 Antagonist 98.65%
    AL 082D06 是一种选择性的非甾体类糖皮质激素受体 (GR) 拮抗剂,Ki 为 210 nM。
  • HY-17461
    Cortisone Agonist 98.63%
    Cortisone是一种用于治疗感染或过敏的激素药物
  • HY-14234
    Glucocorticoid receptor agonist Agonist 98.57%
    Glucocorticoid receptor agonist是Glucocorticoid受体激动剂。
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