1. Signaling Pathways
  2. Anti-infection
  3. Fungal

Fungal

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host. Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Fungal 相关产品 (115):

Cat. No. Product Name Effect Purity
  • HY-12320
    Cycloheximide Inhibitor 99.45%
    Cycloheximide (Naramycin A) 是真核生物蛋白质合成的抑制剂,抑制体内蛋白质合成和RNA合成的 IC50 值分别为532.5 nM 和 2880 nM。
  • HY-B0490
    Hygromycin B >98.00%
    Hygromycin B是抑制原核和真核细胞的氨基糖苷类抗生素。
  • HY-B0221
    Amphotericin B Inhibitor >98.00%
    Amphotericin B是针对多种真菌病原体的多烯抗真菌 (fungal) 剂。 它与麦角甾醇不可逆地结合,导致膜完整性破坏并最终导致细胞死亡。
  • HY-17409
    Nystatin Inhibitor 98.29%
    Nystatin是一种对酵母和支原体有效的多烯抗真菌抗生素。
  • HY-17514
    Itraconazole Inhibitor 99.55%
    Itraconazole是抗真菌剂。
  • HY-16909
    Leptomycin B Inhibitor >98.0%
    Leptomycin B (CI 940; LMB) 是一种蛋白出核转运抑制剂。Leptomycin 通过半胱氨酸残基处的共价修饰使 CRM1/exportin 1 失活。 Leptomycin B 是一种有效的抗真菌抗生素,可阻断真核细胞周期。
  • HY-123230
    Trifloxystrobin Inhibitor
    Trifloxystrobin (CGA 279202) 是一种抗真菌剂 (fungicide),对大型蚤新生儿和胚胎的 EC50 值分别为 23.0 μg/L 和 1.7 μg/L (48 h)。
  • HY-N3006
    Sakuranetin Inhibitor >98.0%
    Sakuranetin 是一种大米黄酮类植物抗毒素,具有很强的抗真菌活性。Sakuranetin 具有抗炎和抗氧化作用,能够改善 LPS 诱导的急性肺损伤。
  • HY-17006
    Caspofungin Acetate Inhibitor 99.72%
    Caspofungin Acetate 是一种抗真菌药,能够非竞争性地抑制1,3-β-d葡聚糖合酶的合成。
  • HY-B0105
    Ketoconazole Inhibitor 99.67%
    Ketoconazole (R-41400) 是咪唑类抗真菌剂,是经典的CYP3A4抑制剂,也是 CYP24A1的抑制剂。
  • HY-16321
    Micafungin sodium Inhibitor >98.0%
    Micafungin sodium (FK 463) 是抗真菌剂,抑制1, 3-beta-D-glucan的合成。
  • HY-B0101
    Fluconazole Inhibitor 99.51%
    Fluconazole是抗真菌化合物,可用于表面和全身性的真菌感染。
  • HY-14273
    Isavuconazole Inhibitor 99.99%
    Isavuconazole 是一种水溶的苯三唑,具有抗真菌作用,同时也是 CYP3A4 的温和抑制剂。
  • HY-76200
    Voriconazole Inhibitor 99.97%
    Voriconazole(UK-109496)是第二代三唑类抗真菌化合物,可作用于严重的真菌感染。
  • HY-B0450
    Ciclopirox Inhibitor 98.76%
    Ciclopirox (Penlac)是合成的抗真菌化合物。
  • HY-17373
    Posaconazole Inhibitor 99.91%
    Posaconazole 是一种广谱的,二代三唑类物质,具有抗真菌作用。
  • HY-B0139
    Flucytosine Inhibitor >99.0%
    Flucytosine(5-Fluorocytosine, 5-FC, Ancobon)是抗真菌化合物。
  • HY-13553
    Anidulafungin Inhibitor 98.98%
    Anidulafungin 是一种新型的半合成棘球白素,具有抗真菌 (antifungal) 效力。
  • HY-17395A
    Terbinafine Inhibitor 99.98%
    Terbinafine (TDT 067) 是治疗真菌感染的抗真菌药物。它是来自念珠菌属的角鲨烯环氧化酶有效的非竞争性抑制剂, Ki值为30 nM。
  • HY-10882
    Clotrimazole Inhibitor 99.62%
    Clotrimazole是咪唑衍生物,有抗真菌活性,是P450抑制剂。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.

幸运飞艇怎么样玩才能赢 幸运飞艇如何玩才能盈利 北京pk10怎样才能注册 快乐时时彩 幸运飞艇怎样才能注册 幸运飞艇pk10好玩吗 快乐时时彩 北京pk10怎样才算中奖 幸运飞艇怎么样 幸运飞艇如何稳赢