1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase

Carbonic Anhydrase

Carbonic anhydrase is a zinc-containing enzyme that catalyzes the reversible hydration of carbon dioxide: CO2+H2O<-->HCO3-+H+. The enzyme is the target for drugs, such as Acetazolamide, Methazolamide, and Dichlorphenamide, for the treatment of glaucoma. There are three evolutionarily unrelated CA families, designated alpha, beta, and gamma. All known CAs from the animal kingdom are of the alpha type. There are seven mammalian CA isozymes with different tissue distributions and intracellular locations, CA I-VII.

Carbonic anhydrase is one of the core enzyme in organism, which involves in osmoregulation, ionic regulation, acid-base regulation and other physiological and biochemical process.

Carbonic Anhydrase 相关产品 (15):

Cat. No. Product Name Effect Purity
  • HY-B0782
    Acetazolamide Inhibitor 99.87%
    Acetazolamide 是一种碳酸酐酶 (carbonic anhydraseCA) IX 抑制剂,抑制 hCA IXIC50 为 30 nM。利尿剂。
  • HY-B0553
    Methazolamide Inhibitor
    Methazolamide是碳酸酐酶抑制剂,可作用于青光眼。
  • HY-B0588
    Brinzolamide Inhibitor 99.78%
    Brinzolamide(AL 4862)是碳酸酐酶(carbonic anhydrase)II抑制剂,IC50为3.19 nM。
  • HY-B0109A
    Dorzolamide hydrochloride Inhibitor 99.47%
    Dorzolamide(L671152; MK507)盐酸盐是碳酸酐酶(CA)抑制剂,可作用于青光眼。
  • HY-B0397
    Dichlorphenamide Inhibitor >98.0%
    Dichlorphenamide(Diclofenamide)是碳酸酐酶抑制剂。
  • HY-13650
    Indisulam Inhibitor 98.92%
    Indisulam (E 7070) 是一种 碳酸酐酶抑制剂,也是细胞周期G1期的靶向化合物。通过抑制细胞周期蛋白依赖型激酶 2 (CDK2) 和周期蛋白 E (cyclin E) 的激活,导致G1/S转化被阻滞。在人结肠癌和肺癌细胞中显示了抗肿瘤活性。
  • HY-B1424
    Benzthiazide Inhibitor >99.0%
    Benzthiazide 是一种长效的利尿剂和抗高血压剂。Benzthiazide 为碳酸酐酶 9 (carbonic anhydrase 9 (CA9)) 的抑制剂,对 CA9,CA2 和 CA1 的 Ki 值分别为 8.0,8.8 和 10 nM。Benzthiazide 能够抑制肿瘤细胞增殖。
  • HY-B1480
    Ethoxzolamide Inhibitor 98.78%
    Ethoxzolamide 是 carbonic anhydrase 的抑制剂,其 Ki 值为 1 nM。
  • HY-108316
    Sultiame Inhibitor 99.11%
    Sultiame 是一种 carbonic anhydrase 抑制剂,广泛用作抗癫痫药。
  • HY-B0782S
    Acetazolamide D3 Inhibitor
    Acetazolamide D3是Acetazolamide氘代化合物标准品。
  • HY-13513
    U-104 Inhibitor 99.55%
    U-104是碳酸酐酶(Carbonic anhydrase)CA IX和CA XII高效抑制剂,Ki值分别为45.1nM和4.5nM。
  • HY-B0109
    Dorzolamide Inhibitor
    Dorzolamide(L671152; MK507)是碳酸酐酶(CA)抑制剂,可作用于青光眼。
  • HY-B0483
    Tioxolone Inhibitor >98.0%
    Tioxolone是金属酶碳酸酐酶(metalloenzyme carbonic anhydrase)I抑制剂,有抗痤疮活性。
  • HY-N0085
    Dimethylfraxetin Inhibitor 99.97%
    Dimethylfraxetin 是一种 Carbonic anhydrase 抑制剂,其 Ki 值为 0.0097 μM。
  • HY-B2147
    2-Aminobenzenesulfonamide Inhibitor 99.88%
    2-Aminobenzenesulfonamide 是碳酸酐酶 IX (carbonic anhydrase IX) 的抑制剂。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately。

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