1. Signaling Pathways
  2. Cytoskeleton
  3. Arp2/3 Complex

Arp2/3 Complex

The intact ARP2/3 complex is first purified from Acanthamoeba castellanii based on its affinity for the actin-binding protein profilin, and is shown to consist of a stable assembly of seven polypeptides. Two of the subunits are actin-related proteins of the ARP2 and ARP3 subfamilies, giving the complex its name.

The ARP2/3 complex possesses little biochemical activity on its own. However, when engaged by nucleation-promoting factor (NPF) proteins, it is activated to initiate the formation of a new (daughter) filament that emerges from an existing (mother) filament in a y-branch configuration with a regular 70° branch angle. This coupling of nucleation and branching by the ARP2/3 complex is referred to as autocatalytic branching or dendritic nucleation, and is central to its functions in vivo.

Polymerization of actin filaments directed by the Arp2/3 complex supports many types of cellular movements。

Arp2/3 Complex 相关产品 (3):

Cat. No. Product Name Effect Purity
  • HY-16928
    Cytochalasin B >99.0%
    Cytochalasin B 是一种能透过细胞的真菌毒素,能够与肌动蛋白丝的有刺端结合,扰乱肌动蛋白聚合物的形成,对 F-actin 的 Kd 值为 1.4-2.2 nM。
  • HY-15892
    CK-636 Inhibitor 98.10%
    CK-636是具有细胞渗透性的Arp2/3 复合体抑制剂,能抑制肌动蛋白的聚合,对人,裂殖酵母和牛的 IC50 值分别为4 μM,24 μM和32 μM。
  • HY-16927
    CK-869 Inhibitor 99.76%
    CK-869 是肌动蛋白相关蛋白 2/3 复合体 (ARP2/3) 的抑制剂,其 IC50 值为 7 μM。
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately。

快乐时时彩 怎样玩幸运飞艇才能赚钱 幸运飞艇怎样玩才赚钱 快乐时时彩 北京pk10怎样做代理 幸运飞艇怎么样倍投 在哪里能玩幸运飞艇 快乐时时彩 北京pk10如何玩才能盈利 幸运飞艇怎样买